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Published on
May 23, 2023 by Charlotte Grainger

5 Best At-Home DNA Tests for Health and Wellness in 2023

5 Best At-Home DNA Tests for Health and Wellness in 2023

Look anywhere for at-home health and wellness tests and you won’t be short of results. The reality is, though, that there are hundreds of DNA testing companies claiming to offer accurate and comprehensive health and wellness kits.

So how do you know which to choose? How do you even know which tests to trust? You don’t want to give out your information to just any company. Especially when it concerns your private health information. That’s why we spent months testing and fact-checking all the health and wellness tests out there. We’ve found 5 DNA tests that truly impressed us. But we also found a lot of tests to avoid, too.

We based our selection on the accuracy, detail, ease of use, and of course, value for money, to bring you the best health and wellness tests available. Our #1 choice is LetsGetChecked because it consistently ranked highly against all of our criteria. 

Short on time? Here are our top picks for at-home health and wellness tests

  • LetsGetChecked – Offers high-value individual tests specializing in male and female health, with super quick results.
  • Everlywell – Comprehensive female and male hormone testing, general wellness kits, and subscription options for regular health screening.
  • Self Decode – Enjoy a lifetime subscription that gives you updated results and insights.
  • MyToolbox Genomics – Ongoing reports and progress updates on your health and wellness journey. 
  • Nebula Genomics – Whole 30X genome sequencing which provides for more details and accuracy in health and wellness reports.

See how each test compares | FAQs

Our Best DNA Test Kits for Health and Wellness Reviewed

1. LetsGetChecked – Best For Individual Health & Wellness Tests

  • Huge bank of individual tests available, from Omega 3 levels to thyroid function and colon cancer risk
  • Male and female-specific wellness tests, including hormone levels and fertility
  • Connect your fitness tracker to your LetsGetChecked dashboard to monitor your health
  • Subscribe and get wellness test deliveries every 3 months
  • Results in 2-5 days

When it comes to choosing a testing service for individual health and wellness needs, LetsGetChecked stands out with its comprehensive test selection. You can find various tests on unique health concerns, such as hormone levels, vitamin deficiencies, or chronic conditions. I like how this vast selection empowers me to take control of my health by focusing on the most important areas.

The at-home convenience offered by LetsGetChecked is another prominent feature. By following the clear instructions on each kit, you can easily collect samples in your own home. I appreciate this approach as it eliminates the need for lengthy doctor’s appointments and encourages you to regularly monitor your health.

Lastly, LetsGetChecked’s personalized wellness insights set it apart from other testing services. You’ll receive tailored recommendations based on your unique health profile, helping you identify areas for improvement and suggesting lifestyle changes as needed. Since this feature equips me with relevant knowledge, I can improve my decision-making and proactively improve my well-being.

Screen Your Health With LetsGetChecked!

2. Everlywell – Best For Female & Male Hormone Testing

  • Detailed female and male hormone testing, including testosterone, progesterone, and thyroid function
  • More individual health tests and STD kits available
  • Subscription options for ongoing health testing
  • Results in 5 days

Everlywell has loads of health tests available, but it’s probably best for its comprehensive female and male hormone kits.

These tests screen for the most common hormones that affect mood, weight, sleep, sex drive, and more. This includes hormones such as testosterone, progesterone, cortisol, and even FT3 which can affect your thyroid function.

You can also choose from a multitude of other health kits, which include a food sensitivity test, allergy screening, vitamin deficiencies, and ovarian reserve kits. It offers sexual health screening, too, with a number of bundles and individual STD tests, which makes it a great all-rounder.

Everlywell offers a subscription service, so you can sign up to receive your chosen test(s) every month, quarter, or twice a year, based on your needs. You can save the most money if you choose the monthly testing option.

Sample collection methods vary depending on the test you choose, but regardless it’s quick and painless. And it only takes up to 5 days to get your results. Your report includes a list of the different biomarkers tested with high, medium, or low levels, alongside personalized advice to help you with your next steps.

Assess your Hormone Levels with Everlywell!

3. Self Decode – Best For Health & Wellness Report Subscriptions

  • Annual and lifetime subscription service with access to tons of reports
  • Screens for everything from heart health to anxiety levels and carrier status
  • Get personalized advice on lifestyle factors and supplements
  • Upload existing DNA from 23andMe, AncestryDNA, and more

SelfDecode offers an annual and lifetime subscription service that gives you access to individual health reports.

You have to buy a one-off DNA test, but once you have your raw data, all you need to do is upload it each time you want a new report.

You can learn about your optimal nutrition profile, risk of inflammatory diseases, sleep quality, cardiovascular health, and thyroid function, plus much more. There are kits that assess your levels of anxiety and cognitive function.

SelfDecode also offers some cancer screening tests, particularly for inherited cancers like breast cancer. It takes 6-8 weeks to get your raw DNA from the initial DNA test. Or if you’ve already taken a test with 23andMe, AncestryDNA, Courtagen, and FamilyTreeDNA, you can upload your raw data right away.

You can use your DNA to screen your health with other testing companies, and simply pick the reports you want from SelfDecode to get your personalized health overview.

You get detailed risk assessment information based on every biomarker tested, plus advice on supplements and other lifestyle changes that can help you.

Sign up for SelfDecode & Unlock Your Wellness Reports!

4. MyToolbox Genomics – Best For Monitoring Progress

  • 300+ health reports from 1,000 analyzed genetic markers
  • Personalized reports on digestive, mental, and skin health
  • Discover your biological age
  • Monitor impact of lifestyle changes with epigenetic testing

From your DNA sample, the health and wellness test from MyToolbox Genomics generates over 300 reports by analyzing 1,000 genetic markers covering 16 traits. Discover your predispositions in digestive, skin, eye, and mental health, as well as how your genes influence weight loss, sleep, immunity, and more.

Your result report includes personalized recommendations to help overcome your predispositions. You’ll get tailor-made diet and supplement advice, plus individual exercise and work-out plans to improve your overall health and wellness.

Upgrade to epigenetics testing and you’ll get lifestyle recommendations to alter your gene expression and with regular testing, you can track your progress. Plus, you’ll get five modifiable aging insights: biological age, eye age, hearing health, memory, and inflammation.

Track Your Progress with MyToolbox Genomics!

5. Nebula Genomics – Best For Whole Genome Sequencing

  • 30 x genome sequencing to uncover all of your DNA
  • Screens for 27 different health and wellness traits
  • Search through tons of sources to learn more about your genetic variants
  • Reports available in 8 weeks

Nebula Genomics offers even deeper insights with 30 x whole-genome sequencing. This means it scans more of your DNA and identifies all of your genetic markers to provide you with a comprehensive health report and raw DNA data that you can take away to explore yourself.

It assesses 27 different health traits, which are arranged into four categories: appearance and hormones, behavior and perception, body and athleticism, and nutrition and diet.

You can learn about factors like your risk of high blood pressure, whether you’re a carrier of genes that can cause hereditary cancers and other health conditions. It can even tell you whether you’re likely to be taller than average or have ‘Jimmy legs’ – a trait that causes you to fidget during your sleep.

Next to each trait, you can see the gene tested and which variant you carry, which makes it simple to understand and research yourself.

You can use the Nebula Genomics exploration tools to learn more about your health with your raw DNA data. It includes a gene analysis tool, variant search tool, and genome browser so you can answer any questions to have about your DNA and nucleic sequence.

The Nebula Genomics test also includes ancestry information, if you’re interested in learning about your mtDNA and YDNA. 

Expect to wait up to 8 weeks for your results. If you choose Nebula, be aware there’s a monthly subscription fee on top of your test cost, or you can pay for lifetime access upfront. If you don’t, you can’t access your results anymore.

Get Whole Genome Sequencing with Nebula Genomics!

How We Tested the Best Health & Wellness Kits

Our team of dedicated wellness experts invested several months in comprehensive testing, extensive research, and thorough comparisons of numerous health tests available in the market. Our goal was to present you with the top recommendations based on our stringent criteria, ensuring you always receive the best value and the most accurate results. Here is a breakdown of what we considered:

  1. Legitimacy – To ensure your trust and safety, we carefully scrutinized the legitimacy of each DNA company. We eliminated any that raised concerns about their credibility. Our initial assessment focused on professional websites that exuded trustworthiness, as nobody wants to engage with a DNA test provider that appears dubious or scammy. We relied on companies with polished, well-designed websites that conveyed a sense of professionalism. Furthermore, we sought out trusted reviews from actual customers to verify the company’s reputation. Surprisingly, we discovered that over 75% of DNA health and wellness companies failed to meet this first criterion.
  2. Accuracy of Results –  We prioritize accuracy in the results provided by each DNA test. Our team extensively evaluated the scientific methodologies employed by the testing companies to ensure that their analyses and interpretations were backed by robust scientific evidence. We considered factors such as the comprehensiveness of the genetic markers analyzed, the quality of the laboratory facilities used, and the precision of the reported outcomes. Only tests with a proven track record of delivering accurate and reliable insights made it onto our list.

  3. Data Security and Privacy – Protecting your privacy and data security is of paramount importance to us. We carefully examined each company’s data protection measures, encryption protocols, and adherence to industry standards. Our recommended tests prioritize secure storage and transmission of genetic information. We specifically looked for companies that allow you to maintain control over your data, granting you the choice of how it is stored, used, and shared. Providers that demonstrated a strong commitment to data privacy and employed rigorous security measures earned our recommendation.

  4. Customer Support – We understand the value of reliable customer support throughout your testing experience. Our evaluation included an assessment of the responsiveness, helpfulness, and professionalism of the customer support teams of each DNA testing company. We looked for providers that offer multiple channels of communication, such as live chat, email, and phone support. The inclusion of clear and comprehensive FAQs, user guides, and educational resources also played a role in our assessment. Companies that prioritize exceptional customer support earned higher rankings on our list.

  5. Cost and Value – We recognize the importance of affordability and value for money. Our team considered the pricing structures of each DNA test, evaluating the overall cost in relation to the provided features, accuracy, and additional services offered. We carefully examined the transparency of pricing, ensuring there were no hidden fees or unexpected charges. Our list comprises tests that provide excellent value, offering a balance between affordability and the quality of insights provided.

  6. Ease of Use – We understand the importance of a seamless and user-friendly testing process. Our team assessed the ease of sample collection, the clarity of instructions, and the simplicity of result interpretation. We favored tests that provided intuitive interfaces, clear guidelines, and accessible platforms for accessing and understanding your results. Our recommended tests prioritize a hassle-free experience, making it convenient for users to navigate through the entire testing journey.

How Accurate Are At-home Health & Wellness Tests?

A DNA health and wellness test should at the very least be medically accurate. It would be extremely dangerous to receive incorrect advice from something falsely claiming to be factual. Before the review process started, we gathered all of our personal known genetic risk factors and medical history reports. We took various saliva, urine, and blood tests and performed genetic testing (with medical doctors) to create a control group of data points.

All of the internet-bought genetic DNA tests needed to show relative consistency within a margin of error against the control for us to recommend them. At the same time, we also compared these DNA health and wellness reports against each other. If there was something similar among them that our extensive pre-testing didn’t show, then it might have shown a flaw in our control group. Thankfully, that didn’t happen.

Every test on this list offers highly accurate results, some even as high as 99.9%. We made sure all the labs are CLIA certified, with qualified physicians available to review your results. But remember, no matter how good the lab, or how great the test, no company can ever offer 100% accuracy.

Can Customer Service Answer All of Your Questions?

As customers, we deserve a certain level of satisfaction in order to justify paying money to one of these DNA testing companies. If we’re paying money, we want that product to be delivered quickly, correctly, and without issue. And, in the rare event that there is an issue, we need to know that it can be rectified ASAP. So, we made sure every test on this list offers:

  • Easy-to-understand testing procedures and health reports
  • Various support channels (24/7 live chat support is the gold standard)
  • A detailed refund policy if the service hasn’t been delivered correctly

Which Test Gives You the Best Value For Money?

At-home DNA testing isn’t always cheap, so we wanted to make sure you really get your money’s worth with whichever test you choose. From initial test fees and shipping costs, to the detail in your report and on-going support, we looked at everything on offer. And you’re probably wondering which test on this list actually offers the best value of them all.

I’d have to say LetsGetChecked delivers the best value for money. Aside from the fact it has thousands of overwhelmingly positive reviews from customers, it’s also very budget-friendly and comes with the most insightful health report. Remember, though, the best value for you also depends on what you need from your test.

If you’re hoping your health test can identify food intolerances, a kit that screens for heath carrier risks probably won’t fit the bill. That’s why we’ve recommended a varied list of health tests to suit everyone’s needs – and budgets.

Which Health & Wellness DNA Test Should You Choose?

Your perfect health and wellness test depends on a lot of factors, including how quickly you need results, what you’re hoping to learn from your results and obviously, how much money you want to spend.

You might consider LetsGetChecked if you’re looking to assess specific aspects of your health, or you want tests engineered specifically for males and females. It’s also a good choice for urgent health testing since it turns around your results in just 2-5 days.

Go for Everlywell if you’re interested in regular health testing. For a set monthly fee, you can pick a new health test every month to get more health insights. It’s also a good option for male and female hormone testing.

If you’re really interested in optimizing your diet and fitness, and monitor your progress, go for MyToolbox Genomics.  It gives you excellent diet, fitness, and exercise tips. Plus, you can monitor the impact your lifestyle changes have on gene expression with regular epigenetics testing.

  Specialty Free shipping Free Medical Consultancy Results ETA Starting Price
LetsGetChecked Male and female health testing, and sexual health 2-5 days $69.00
Everlywell Hormone and sexual health testing 5 days $99.00
My Toolbox Genomics Nutrition and fitness 4-6 weeks $199.00
SelfDecode General health and wellness, and behaviors and traits 6-8 weeks $199.00
Nebula Genomics Whole-genome sequencing 8 weeks $299.00


What does a health and wellness DNA test tell you?

A health and wellness test can tell you many things, from how your body metabolizes different foods, to whether you carry the genes for certain health conditions. Here are some common things a health and wellness test can tell you:

  • Whether you’re at risk of certain health conditions
  • If you carry the genes for any genetic diseases
  • Your overall nutritional health and optimal diet 
  • Your body’s vitamin and mineral deficiencies 
  • Your personality traits and behaviors

How do you read and interpret the results of a health and wellness DNA test?

Most reports offer a PDF download or online report to interpret your results. Usually, your report includes a list of the biomarkers tested for each aspect of your health alongside your specific genetic variants.  For health conditions or diseases, a report will often tell you your risk level, particularly whether you have a low, medium, or high risk of developing a health condition. Some testing services like LetsGetChecked provide access to a genetic counselor or other professional to help you interpret your results. And others even offer personal health coaching.

Can a health and wellness DNA test determine if you have cancer? 

No. A DNA test can only tell you if you’re genetically at a higher risk of getting cancer than other people in the population. It gives you an indication that you should be taking preventative measures or talking to your doctor about the kinds of cancer that are identified. You should always take your results to your doctor to get diagnosed correctly.

What general medical conditions can health and wellness DNA tests show?

Most DNA tests screen for risks associated with various types of cancer and heart disease, along with degenerative disorders like Alzheimer’s and Parkinson’s. Many will also tell you if you carry a certain genetic marker that could be passed down to your children.

What common genetic wellness traits can you find out?

Your DNA contains a lot of information about things that make you unique. As well as physical features like hair thickness and skin type, DNA tests can predict the most obscure behaviors, such as your favorite ice cream flavor or whether you have a fear of heights. You can also learn about your likelihood of developing mental health conditions, such as anxiety or depression, and your overall cognitive ability.

What are carrier status reports? 

A carrier status report tells you if you carry specific genetic markers for conditions that could be passed on to your children if your partner has the same gene variants.

What is a genetic predisposition? 

A genetic predisposition means your DNA makes it more likely that you will develop a specific disease (or diseases), based on environmental conditions. It doesn’t mean you’ll definitely develop the disease, but it does mean you are more likely to than most people.

What is cellular aging?

Cellular aging refers to your cells’ reduced ability to resist stress and other cellular damage over time. The DNA in your cells can get damaged when the telomeres that cap the ends of your chromosomes get shorter, just as your shoelaces start to fray when the plastic caps on their ends wear away.

Can a health and wellness DNA test tell your age?

The length of the telomeres that cap off your chromosomes can be measured to give an indication of your “biological age,” which may well be different from your chronological age (i.e., how long you have been alive).  

Should you share your health and wellness DNA report with a doctor? 

Yes. In general, it’s a good idea to share anything related to your health with your doctor. Sharing your results is especially important if you are genetically predisposed to certain conditions or if your DNA suggests that you could react adversely to some pharmaceuticals. Your doctor will be able to arrange an official medical diagnosis for any health conditions you’re identified as being at high risk of. They can also coordinate your care effectively and make sure you receive the right treatment.

About Author
Charlotte Grainger
Charlotte Grainger
Charlotte Grainger

I am freelance journalist and content writer living in Sheffield. I hold a BA in Journalism and an MA in Creative Writing. When I'm not working, you can find me at the gym or hanging out with my cat, Harry.

I am freelance journalist and content writer living in Sheffield. I hold a BA in Journalism and an MA in Creative Writing. When I'm not working, you can find me at the gym or hanging out with my cat, Harry.